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Head DMPK (m/f/d) in der Städteregion Aachen
Referenznummer: acjobs-st-68299

Grünenthal GmbH - Vollzeitbeschäftigung
Start ab sofort - Online seit dem 27.10.2020


Job-Zusammenfassung

Grünenthal is a global leader in pain managementrelated diseases. We’re driven to seek effective, life-changing medicinessolutions for patients with severe diseaseshigh unmet medical needs. We’re focussing all of our activitiesefforts on moving towards our vision of a world free of pain. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatmentsstate-of-the-art technologies to people living with pain worldwide.
Grünenthal is headquartered in Aachen, Germany,has affiliates in 30 countries across Europe, Latin Americathe US. Our products are sold in more than 100 countries. In 2018, we employed around 4,900 peopleachieved sales of € 1.3 billion.
As a player in an innovative, fast-paced market, we offer an exciting working environmentwide-ranging individual development opportunities. Our sharedform the basis for the way we work: We embrace diversity, put patients at the centre of our decisions, live entrepreneurship,forces, drive performanceact with integrity. us at Grünenthal, unleash your full potentialhelp us change lives for the better. Job fact summary
Job ID: 36976
Head DMPK (m/f/d)
Research & Development
Aachen
published 08.10.2020
Head DMPK (m/f/d)
You are accountable for developing DMPK strategies to build a portfolio of high quality clinical candidates, including translational PKPD understandingnon-clinical models, leading to a prediction of clinical pharmacokinetics, efficacioustolerable dose/schedules and  potential drug-drug interaction profileinterpreting clinical studies
You leaddevelop DMPK team to support lead optimization, IND-enabling programsclinical PoC
You ensure in time delivery of preclinicaltranslational DMPK work packageearly drug discovery to launchlife cycle management
You establish DMPK strategies that align with program goalsstrive for high quality clinical candidates
You integrate CRO DMPK/PD, bioanalytical,biotransformation data to address key issuesenable informed, timely decision making
You design, managereview CRO preclinical studies to understand  DMPK profile of candidates to influence discovery decisionssupport IND-enabling studiesclinical development
You drive human dose projection calculationssupport clinical pharmacology trial design based on DDI risk analysis based on nonclinical datarefining based on clinical data
You demonstrate high proficiency across a wide range of in vitro/ in vivo DMPK technologiesbeing capable of initiating new areas of investigation that are scientifically meaningful in supporting drug discoverydevelopment programs

You hold a PhD in Drug Metabolism/ Pharmacokineticsrelated discipline
You have several years of relevant experience in DMPK with several years of experience as a line manager in drug discoverydevelopment with track record of taking molecules to the clinicbeyond
You have a track record of developingleading a strong scientifically data driven DMPK team to support both researchclinical stage programs
You have a broad understanding of various DMPK relevant areas such as physicochemical properties, drug metabolizing enzyme & transporter kinetics, pharmacokinetics, mechanistic biotransformation, analytical sciencesPK/ dose modelling
You are experienced in interpreting met-id dataproposing metabolic pathways across species
You have extensive experience in managing CROs, GLPother regulated activities
You have outstanding problem-solving skills, with proven ability to integrate across disciplines to address issuesidentify mitigation strategies

Bitte geben Sie bei Ihrer Bewerbung die Referenznummer acjobs-st-68299an.


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